Parası kalmadığı için otobüse binemiyordur ailesi porno izle ona daha yeni para gönderdiği için tekrar porno istemeye utanınca mecburen otostop çekmek için youporn çantasını alarak yol kenarına gelir etekli porno liseli türk kız yol kenarında dururken yanına yaklaşan porno kibar bir gencin onu gideceği yere kadar bırakmak porno izle istemesine çok mutlu olur arabaya bindiklerinde gideceği yer ile porno arabayı kullanan adamın gittiği yer arasında çok mesafe sex izle farkı olduğunu anlayan türk kız bu yaptığı porno indir iyilik karşısında arabada ona memelerini açar porno sapıklaşan adam yol kenarındaki hotelde durarak porno izle üniversiteli otostop çeken türk kızına odada sakso çektirip sikerEnhancement of Dissolution Rate of Aceclofenac by Solid Dispersion Technique| Abstract

44 7460 854 031

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Enhancement of Dissolution Rate of Aceclofenac by Solid Dispersion Technique

Author(s): T. V. Rao and S. Vidhyadhara

Aceclofenac, a selective cyclooxygenage inhibitor is used in the treatment of rheumatoid arthritis and ankylosing spondylitis. One of the major problems with the drug is that, it is practically insoluble in water, which results in poor bioavailability after oral administration. In the present study, solid dispersions of aceclofenac were prepared by solvent evaporation method with two hydrophilic carriers such as poly vinyl pyrrolidine (PVPk-30), and PEG-6000 were used in the ratio of (drug : carrier) 1 : 1, 2 : 1, and 3 : 1, respectively. Prepared solid dispersions were subjected to IR study for determining any interaction between drug and carriers. Study showed no interaction between drug and carriers. Solid dispersions were subjected for determination of percentage drug content, particle size analysis and in vitro dissolution study. The dissolution rate studies were performed in phosphate buffer pH 6.8 using USP XXII type-2 apparatus. Solid dispersion in the ratio of 2 : 1 (Drug : PVPk-30) gave faster dissolution rate than other SDs, corresponding physical mixtures and pure drug.


Share this       
Google Scholar citation report
Citations : 4955

International Journal of Chemical Sciences received 4955 citations as per Google Scholar report

Indexed In

  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research

Read More

Flyer
Yeni acilan ve cok kazancli olan Matadorbet guncel giris yapip uyelik gerceklestirebilirsiniz.