Parası kalmadığı için otobüse binemiyordur ailesi porno izle ona daha yeni para gönderdiği için tekrar porno istemeye utanınca mecburen otostop çekmek için youporn çantasını alarak yol kenarına gelir etekli porno liseli türk kız yol kenarında dururken yanına yaklaşan porno kibar bir gencin onu gideceği yere kadar bırakmak porno izle istemesine çok mutlu olur arabaya bindiklerinde gideceği yer ile porno arabayı kullanan adamın gittiği yer arasında çok mesafe sex izle farkı olduğunu anlayan türk kız bu yaptığı porno indir iyilik karşısında arabada ona memelerini açar porno sapıklaşan adam yol kenarındaki hotelde durarak porno izle üniversiteli otostop çeken türk kızına odada sakso çektirip sikerEffect of Hydroxylpropylated beta Cyclodextrin and pH on Solubility of Telmisartan| Abstract

44 7460 854 031

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Abstract

Effect of Hydroxylpropylated beta Cyclodextrin and pH on Solubility of Telmisartan

Author(s): B. D. Shewale, P. O. Patil, P. K. Deshmukh and R. A. Fursule

The present study was undertaken to examine the effect of pH and concentration of hydroxypropylated-0-cyclodextrin (HP-0-CD) on the solubility of telmisartan as it shows the pH dependent solubility. The equilibrium solubility of telmisartan in a series of solutions of varying pH (from 1.2 to 11) was determined and compared with the equilibrium solubility of telmisartan in the presence of 20% HP-0-CD at same pH values. It was observed that solubility of protonated form is more than the neutral molecule. HP-0-CD resulted in increased solubility at all the pH. But inclusion in the cavity of HP-0-CD might depend upon charge state of the molecule. So it can be concluded that solubility of telmisartan can be increased either by the addition of HP-0-CD or by adding pH lowering agents. If both these methods are to be used together, pH should be selected carefully.


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