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Drug Delivery System: Matrix

Author(s): Nima Kizaki

These are the types of controlled drug delivery systems that use both dissolution and diffusion control mechanisms to continuously release the drug. The drug is disseminated in swellable hydrophilic substances, an insoluble matrix of rigid non-swellable hydrophobic materials, or plastic materials to control the release of medications with various solubility qualities. Direct compression of a blend of a drug, retardant material, and additives to make a tablet in which the drug is embedded in a matrix of the retardant material is one of the simplest techniques to the fabrication of sustained-release dosage forms. Before compression, the medication and retardant blend could be granulated. Both hydrophilic and hydrophobic polymers are commonly employed in the creation of matrix systems. Hydroxypropylmethylcellulose (HPMC), Hydroxypropylcellulose (HPC), Hydroxyethylcellulose (HEC), Xanthan gum, Sodium alginate, Poly (ethylene oxide), and cross-linked homopolymers and copolymers of Acrylic acid are all common hydrophilic polymers.

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