Development of Transmucosal Delivery System for Propranolol Hydrochloride using Novel Natural Polysaccharide

Author(s): Shaik Wajid Pasha, Mohammad Arief, Bonthu Satyanarayana, P. Ravi Shanker and Shaik Irfan Pasha

The objective of the present study was designed to overcome the hepatic first pass metabolism and enhance the bioavailability, as it is the major disadvantage of the oral drug delivery, for that Buccal route of administration is one of the routes of choice for the administration of drugs that undergo extensive first pass metabolism. Natural plant polysaccharides, su ch as gums and mucilages find a wide variety of applications in pharmaceutical formulations. Commonly they are used as binding agents, disintegrating agents, sustaining agents in matrix tablets, film forming agents, gelling agents, suspending and emulsifying agents, and as coating agents for granule coating and microencapsulation. Tshe gum from Prunusamygdalus exhibited very good mucoadhesive properties. Hence, the objective of the present study was to formulate unidirectional, b ilayered, mucoadhesive tablets fo r buccal delivery of propranolol hydrochloride using Prunusamygdalus. So Different shaped bilayered unidirectional buccal tablets were prepared taking different concentrations of polymer, among these bilayers one is drug containing layer which compressed with drug, polymer, avicel PH 101 and magnesium stearate using KBR pellet machine by maintaining 1 ton pressure another layer was ba cking layer compressed with ethyl cellulose and evaluated for all possible parameters and also conducted in vivo studies using 6 human volunteers. It can be stated that the formulated unidirectional, bilayered, mucoadhesive tablets of propranolol hydrochloride using natural polysaccharide as mucoadhesive polymer were able to bypass the first pass metabolism associated with oral administration and improves the bioavailability of the drug.

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