Parası kalmadığı için otobüse binemiyordur ailesi porno izle ona daha yeni para gönderdiği için tekrar porno istemeye utanınca mecburen otostop çekmek için youporn çantasını alarak yol kenarına gelir etekli porno liseli türk kız yol kenarında dururken yanına yaklaşan porno kibar bir gencin onu gideceği yere kadar bırakmak porno izle istemesine çok mutlu olur arabaya bindiklerinde gideceği yer ile porno arabayı kullanan adamın gittiği yer arasında çok mesafe sex izle farkı olduğunu anlayan türk kız bu yaptığı porno indir iyilik karşısında arabada ona memelerini açar porno sapıklaşan adam yol kenarındaki hotelde durarak porno izle üniversiteli otostop çeken türk kızına odada sakso çektirip sikerDevelopment of Analytical Method for Simultaneous Estimation of Doxofylline and Salbutamol Sulphate in Combined Dosage Form| Abstract

44 7460 854 031

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Abstract

Development of Analytical Method for Simultaneous Estimation of Doxofylline and Salbutamol Sulphate in Combined Dosage Form

Author(s): S. E. Chaudhary, C. K. Gadewar, A. P. Dewani and A. V. Chandewar

A simple and sensitive HPLC method has been developed for the simultaneous estimation of doxofylline (DOX) and salbutamol sulphate (SAL) in combined dosage form. Doxofylline is bronchodilator. It is a xanthine derivative and a bronchial muscle relaxant, It also relaxes vascular smooth muscle in pulmonary blood vessels. Salbutamol sulphate is beta-adrenoreceptor agonist. It is chemically related to isoprenaline. It has a prominent brochodialator (ß-2 receptor) and poor cardiac (ß-1) stimulant action as compared to isoprenaline. The HPLC method was developed by using C18 Inertsil column (250 mm length, 4.6 mm internal diameter and 10 μm particle size) using mobile phase methanol : water : glacial acetic acid (80 : 19 : 01% v/v/v) at a flow rate of 1.0 mL/min, on an isocratic HPLC, Monitoring was done by a UV detector at 239 nm. Retention time of DOX and SAL was found to be 3.233 min. and 2.19 min. respectively. The method was statistically validated for its linearity, accuracy and precision. The developed method was simple and accurate. This method can be used for routine quality control of doxofylline and salbutamol sulphate in bulk and in formulations.


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