Development and Validation of Spectrophotometeric Methods for the Estimation of Cefditoren Pivoxil

Author(s): S. Appala Raju, Arvind B. Karadi and Shobha Manjunath

Three simple sensitive and economical spectrophotometric methods (A, B and C) for the quantitative estimation of cefditoren pivoxil in bulk drug and pharmaceutical dosage from have been developed. Method-A is based on UV absorption of drug in 0.1 N hydrocholoric acid exhibiting absorption maximum at 233 nm and it obyes Beer’s law in the concentration range of 1 to 5 μg/mL. Method-B (MBTH) is based on oxidation followed by coupling reaction of cefditoren pivoxil with 3- methyl-2-benzothiazolinone hydrazone (MBTH) in presence of ferric chloride to form purple coloured chromogen with absorption maxima max at 435 nm and obeyed Beer’s Law in the concentration range of 5-25 μg/mL. Method-C is based on the reaction of drug with folin-ciocalteau (FC) reagent in alkaline condition to from a stable blue coloured chromogen with absorption maximum at 760 nm and obeyed Beer’s law in the concentration range of 4 to 20 μg/mL. The results of the analysis for the three methods have been validated statically and by recovery studies. These method have been successfully extended to the pharmaceutical preparations (tablets) containing cefditoren.

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