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Development and Validation of RP-HPLC Method for the Estimation of Alfuzosin Hydrochloride in Bulk and Pharmaceutical Dosage Forms

Author(s): Yunoos Mohammad and B. Jagadeesh

A simple, rapid, accurate, precise and reproducible reverse phase high performance liquid chromatographic method has been developed for the estimation of alfuzosin hydrochloride (AFZ) in bulk and in pharmaceutical formulations. The quantification was carried out using Cyberlab capcell pak, ODS C18 (250 × 4.6 mm i.d., 5 μm particle size) column in an isocratic mode, with mobile phase comprising water : acetonitrile : methanol in the ratio of 75 : 15 : 10 (% v/v/v ).The flow rate was at 0.8 mL/min and the detection was carried out at 246 nm. The retention time of the drug was found to be 2.59 min and the method produced linear response in the concentration range of 2-12 μg/mL (R ~ 0.9997). The recovery studies were also carried out and % RSD from reproducibility was found to be 0.334. The proposed method was statistically evaluated and can be applied for routine quality control analysis of alfuzosin hydrochloride in tablets.

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