Parası kalmadığı için otobüse binemiyordur ailesi porno izle ona daha yeni para gönderdiği için tekrar porno istemeye utanınca mecburen otostop çekmek için youporn çantasını alarak yol kenarına gelir etekli porno liseli türk kız yol kenarında dururken yanına yaklaşan porno kibar bir gencin onu gideceği yere kadar bırakmak porno izle istemesine çok mutlu olur arabaya bindiklerinde gideceği yer ile porno arabayı kullanan adamın gittiği yer arasında çok mesafe sex izle farkı olduğunu anlayan türk kız bu yaptığı porno indir iyilik karşısında arabada ona memelerini açar porno sapıklaşan adam yol kenarındaki hotelde durarak porno izle üniversiteli otostop çeken türk kızına odada sakso çektirip sikerDevelopment and Validation of RP-HPLC Method for the Determination of Tenofovir Disoproxil in Bulk and in Pharmaceutical Formulation| Abstract

44 7460 854 031

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Development and Validation of RP-HPLC Method for the Determination of Tenofovir Disoproxil in Bulk and in Pharmaceutical Formulation

Author(s): Zaheer Ahmed, Sathish Kumar Shetty, B. Gopinath, Manzoor Ahmed and B. K. Sridhar

Tenofovir disoproxil (TD) is a prodrug of tenofovir. It is a novel antiviral drug, which is highly efficient in the treatment of human hepatitis B virus (HBV) and HIV. A simple, selective, linear, accurate and precise RP-HPLC method was developed and validated for routine analysis of tenofovir disoproxil in bulk and in pharmaceutical formulation. Isocratic elution at a flow rate of 1.0 mL/min was employed on a Thermo Hypersil HyPURITY C18 reversed-phase column (150 mm × 2.1 mm i.d., 5 µm) at ambient temperature. The mobile phase consisted of acetonitrile and 0.05 mM phosphate buffer pH 6.0 (50 : 50, v/v). The UV detection wavelength was 260 nm and 20 µL of sample was injected. The retention time for tenofovir disoproxil is 4.45 min. Determining sensitivity, accuracy, precision, robustness, stability, specificity, selectivity, and system suitability parameters validated the proposed method.


Share this       
Google Scholar citation report
Citations : 4955

International Journal of Chemical Sciences received 4955 citations as per Google Scholar report

Indexed In

  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research

Read More

Flyer
Yeni acilan ve cok kazancli olan Matadorbet guncel giris yapip uyelik gerceklestirebilirsiniz.