All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Design and Synthesis of Anti-Inflammatory Potential of Novel Quinazoline-4(3h)-Ones Linked Thiazenes Through Amide Linkage: Docking Studies

Author(s): Jagadeesh Babu Vadlakonda, M Srinivasa Murthy and M Saritha

In an effort to develop an anti-inflammatory agent, we have designed and synthesized a new scaffold by linking quinazolinones with thiazine through an amide linkage. The synthesized compounds were characterized by 1H NMR, 13C NMR FTIR and mass spectral data and tested for in-vivo antiinflammatory activity using Carrageenan induced paw inflammatory model as well as docking studies were performed in order to elucidate structural insights for the anti-inflammatory activity. The investigation of anti-inflammatory activity screening and docking results suggested that the compound QTA-a showed good anti-inflammatory activity among the tested compounds.


Share this       
Google Scholar citation report
Citations : 9398

International Journal of Chemical Sciences received 9398 citations as per Google Scholar report

Indexed In

  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research
  • ICMJE

View More