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Abstract

Design and Synthesis of Anti-Inflammatory Potential of Novel Quinazoline-4(3h)-Ones Linked Thiazenes Through Amide Linkage: Docking Studies

Author(s): Jagadeesh Babu Vadlakonda, M Srinivasa Murthy and M Saritha

In an effort to develop an anti-inflammatory agent, we have designed and synthesized a new scaffold by linking quinazolinones with thiazine through an amide linkage. The synthesized compounds were characterized by 1H NMR, 13C NMR FTIR and mass spectral data and tested for in-vivo antiinflammatory activity using Carrageenan induced paw inflammatory model as well as docking studies were performed in order to elucidate structural insights for the anti-inflammatory activity. The investigation of anti-inflammatory activity screening and docking results suggested that the compound QTA-a showed good anti-inflammatory activity among the tested compounds.


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Citations : 4955

International Journal of Chemical Sciences received 4955 citations as per Google Scholar report

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  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research

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