Parası kalmadığı için otobüse binemiyordur ailesi porno izle ona daha yeni para gönderdiği için tekrar porno istemeye utanınca mecburen otostop çekmek için youporn çantasını alarak yol kenarına gelir etekli porno liseli türk kız yol kenarında dururken yanına yaklaşan porno kibar bir gencin onu gideceği yere kadar bırakmak porno izle istemesine çok mutlu olur arabaya bindiklerinde gideceği yer ile porno arabayı kullanan adamın gittiği yer arasında çok mesafe sex izle farkı olduğunu anlayan türk kız bu yaptığı porno indir iyilik karşısında arabada ona memelerini açar porno sapıklaşan adam yol kenarındaki hotelde durarak porno izle üniversiteli otostop çeken türk kızına odada sakso çektirip sikerComparative Evaluation of Theophylline Microsphere prepared using Various Biodegradable Polymers| Abstract

44 7460 854 031

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Abstract

Comparative Evaluation of Theophylline Microsphere prepared using Various Biodegradable Polymers

Author(s): G. Vinothapooshan, N. Jawahar, R. Kalirajan, S. Jubie, K. S. Remya and Prashant S. Wake

The present investigation was to formulate theophylline loaded microspheres using different grade of chitosan, chitosan - sodium alginate and chitosan-albumin by the following methods such as phase separation emulsification, modified ionotropic gelation and heat stabilization method. The prepared microspheres were evaluated in terms of drug content, incorporation efficiency, micromeritic studies, moisture content and in vitro drug release profile. Chitosan –sodium alginate combination produced microspheres with spherical, smooth surface and frees flowing. It exhibited incorporation efficiency above 75% and size range between 999-994 μm. The drug release from the microspheres follows first order kinetics and the mechanism is Higguchi’s diffusion. Theophylline loaded microspheres prepared from Chitosan–sodium alginate combination exhibited good sustained release characteristics and was found suitable for chronic obstructive pulmonary disease (COPD) and nocturnal asthma.


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