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Biochemical Study for Bismuth Oxide and Tellurium Nanoparticles on Thyroid Hormone Levels in Serum and Saliva of Patients with Chronic Renal Failure


Noble metals nanoparticles (NPs) were synthesized directly by pulsed laser ablation (Nd : YAG, λ = 1064 nm) of bismuth and tellurium plates immersed in pure water. Concentrations of the NPs were determined by Atomic Absorption Spectroscopy (AAS) measurement. Atomic Force Microscope (AFM) and Transmission Electron Microscope (TEM) analysis were used to characterize the size and size distributions of the metals NPs. The objective of this work is studying the effects of presence of these NPs on the levels of tri-iodothyronine hormone (T3) in serum and saliva of patients with chronic renal failure (CRF) their thyroid had disorder (hypothyroidism). Also the study characterized the binding between the anti-T3 antibody with its antigen i.e., T3 in serum and saliva patients in the presence affixed size concentration of NPs to improve and modify a competitive ELISA method. It is found that both bismuth oxide and tellurium NPs demonstrated different effect (activation or inhibition) on the binding between anti-T3 antibody and antigen (T3) in the serum and saliva of patients and these effects were depending on the increasing of the concentrations and size for both NPs. In conclusion, both bismuth oxide and tellurium NPs can be useful in biomedical applications such as the treatment and follow up by adjustment the levels of thyroid hormones of patients suffered from thyroid disorder

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