Area Under Curve and Second Order Derivative Spectroscopy of Metaxalone in Bulk Drug and Tablet Formulation

Author(s): J. Priyadharisini, G. P. Gigi, V. Niraimathi and A. Jerad Suresh

Two simple, accurate, and precise spectrophotometric methods have been developed for metaxalone in pharmaceutical dosage form. Metaxalone has absorbance maxima at 278 nm. Method-A is area under curve (AUC) method, which involves the calculation of integrated value of absorbance with respect to wavelength between 246-288 nm Method-B involves the derivatisation of the primary absorption spectra for the second order. The amplitude (DL) of the long wave peak satellite of the second order curve was measured in mm. Beer’s law is obeyed in the concentration range of 40-240 µg/mL in these two methods. The results of analysis were validated statistically and the recovery studies were found to be satisfactory. The additives and common excipients did not interfere in their determinations.

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