All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Anti-Histamine Activity of Newly Synthesized Pyrimidines

Author(s): Y. Rajendra Prasad and S. A. Rahaman

Pyrimidines are one of the most important class of heterocyclic compounds with a variety of biological activities. Keeping this in view, it was proposed to synthesize some novel pyrimidines from chalcones. The condensation of chalcones of 4'-piperzine acetophenone with guanidine hydrochloride gives pyrimidines. The structures of the synthesized compounds RCP1-5 were assigned on the basis of elemental analysis, IR and 1H NMR spectroscopy data. These compounds were also screened for their anti-histamine activity. The recorded % of histamine inhibition showed significant anti-histamine activity, when compared with standard antihistamine drug mepiramine.

Share this       
Google scholar citation report
Citations : 4270

International Journal of Chemical Sciences received 4270 citations as per google scholar report

Indexed In

  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research

Read More