44 7460 854 031

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Anticonvulsant Activity of Hydro-Alcoholic Extract of Leaves of Calotropis Gigantea Linn

Author(s): Y. Kotresh, M. V. Ramana, G. Gopal, G. Vyshnav, K. Lalitha and S. Nagamani

Calotropis gigantea linn is a perennial shrub, commonly known as milkweed or wasteland weed. It belongs to family Asclepiadaceae and was evaluated for its anticonvulsant activity. The leaves were extracted with 70% ethanol and concentrated to obtain residue. The hydro-alcoholic extract (HLE) at a dose of 400 mg/kg b.w, 300 mg/kg b.w, 200 mg/kg b.w and 100 mg/kg b.w by i.p route were tested for their anticonvulsant property against Maximum Electric Shock (MES) induced convulsion model in Swiss albino mice of either sex weighing between 18 g -22 g. A significant (p < 0.01) anticonvulsant activity had been observed in the HLE (400 mg/kg b.w and 300 mg/kg b.w) followed by HLE (200 mg/kg b.w and 100 mg/kg b.w) when compared to control group. Phytochemical screening reveals the presence of alkaloids, cardiac glycosides, flavonoids, steroids, tannins, triterpenoids, carbohydrates and saponins in the hydroalcoholic leaf extract of Calotropis gigantea linn.


Share this       
Google Scholar citation report
Citations : 9398

International Journal of Chemical Sciences received 9398 citations as per Google Scholar report

Indexed In

  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research
  • ICMJE

View More