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Analytical Method Development of Bicalutamide Tablet for Dissolution Test

Author(s): N. Kannapan, S. P. Nayak, K. Dhanlakshmi and R. Mannavalan

The present work is concerned with the objective to develop and validate a new simple, rapid, efficient, reliable and economic method for analysis of dissolution characters of bicalutamide tablets which is a non steroidal anti-androgen.A literature review reveals that only pharmacologically and spectrophotometric determination have been reported in the bulk drug and in its dosage form .It shows absorption maximum at 272 nm in the range 6-158g.Hence analytical method for dissolution of bicalutamide 50mg tablet was developed using multiple point standardization method, where method used met the parameters such as specificity, precession, linearity, range as per ICH guidelines.

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