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Analysis of Amisulpride in Pharmaceutical Dosage Forms by Noval Spectrophotometric Methods

Author(s): P. Ravi Sankar, Ch. Devadasu, S. Sowjanya, P. Srinivasa Babu and G. Devala Rao

Two simple, accurate, sensitive, precise and economical spectrophotometric methods have been developed for the determination of amisulpride (AMS) in tablet formulation. The developed methods were based on the formation of a yellow coloured chromogen due to the reaction of amisulpride with methyl orange (method-I) and formation of a blood-red coloured complex resulted from the reaction of amisulpride with 2, 5-dihydroxy, 3, 6-dichloro-1, 4-benzoquinone (method-II). The proposed methods showed the absorption maxima at 420 nm, 545 nm and have good linearity in the concentration range of 5- 25 μg/mL and 50-250 μg/mL for method-I and method-II respectively. The results of analysis for the proposed methods were validated statistically by recovery studies.

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