An Efficient One Pot Three Component Synthesis of 4-Aryl-6-(3-Coumarinyl) Pyrimidin-2 (1h)-Ones Under Solvent Free Conditions

Author(s): B. Prasanna, K. Praveen Kumar, N. Rakesh and Y. Prashanthi

Silica gel supported zirconyl chloride octahydrate was found to be an efficient and recyclable catalyst for the synthesis of a series of biologically important molecules in high turnover numbers and rates. Substituted 4-aryl-6-(3-coumarinyl) pyrimidin-2 (1H)-ones can be prepared in high yield and purity by direct reaction via., cyclocondensation of urea and 3-acetylcoumarin with substituted aldehydes in the presence of a catalytic amount of ZrOCl2.8H2O/SiO2 as Lewis acid and at ambient temperature under solvent-free conditions. The synthesized compounds 4(a-e) were characterized by IR, NMR and Mass spectral analysis.

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