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An Efficient and Stereoselective Synthesis of S-(+)-Pregabalin Using a Chiral Auxiliary Reagent

Author(s): Vinigari K, Murugan RN, Noorjahan M and Mangatayaru KG

A highly efficient and enantio selective synthesis of (S)-3-amino-5-methylhexanoic acid 1 (Pregabalin) is reported. Evans enolate based asymmetric alkylation reaction was used as the key step to set up the required chirality. This procedure allows the rapid process to provide the (S)-(+)-Pregabalin 1 in excellent overall yields and purity.

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Citations : 9398

International Journal of Chemical Sciences received 9398 citations as per Google Scholar report

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  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research

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