A High Performance Liquid Chromatographic Assay For Lercanidipine Hydrochloride

Author(s): S. Appala Raju, Arvind B. Karadi and Shobha Manjunath

A simple, rapid and reproducible high performance reversed phase liquid chromatographic method has been developed for the estimation of lercanidipine hydrochloride in bulk drug samples and pharmaceutical dosage forms using RPC-18 column. The mobile phase consists of buffer solution and acetonitrile in the ratio 650 : 350, respectively, and was pumped at 1.0 mL/min at 30°C. The detection was carried out at 205 nm and the calibration curve was linear in the range of 0.1 μg/mL to 20 μg/mL. The method was statistically validated for its linearity, precision and accuracy. The intra and inter-day variation was found to be less than 1% showing high precision of the assay method. Due to its simplicity, rapidness, high precision and accuracy, the proposed HPLC method may be used for determining lercanidipine hydrochloride in bulk drug samples or in pharmaceutical formulations.

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