In recent years, nanotechnology has developed to a stage that makes it possible to produce, characterize and specifically tailor the structural and functional properties of nanoparticles for clinical applications. Cartilage damage is typically associated with work and athletic injuries, and commonly occurs in conjunction with ACL tears and other ligament problems. Cartilage does not grow back, so treatments to regenerate the tissue are critical. The new biomedical therapy involving nanotechnology promotes the growth of new, stronger cartilage to aid in the treatment of joint injuries. This review article analyses the various technologies available for the diagnostic and therapeutic potentials of nanotechnology towards chronic arthritis.