All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Synthesis and Biological Evaluation of 4-Aryl - 3-Chloro 1 Nicotinamido 2 Azetidinones as Potential Anticonvulsant and Antimycobacterial Agents

Author(s): N. Ramalakshmi, R. Vijayakumar, K. Ilango, S. Arunkumar and A. Puratchikody

In the present study novel series of 4 - aryl – 3 - chloro – 1 – nicotinamido – 2 -azetidinones were synthesized and characterized by means of IR, 1H- NMR, Mass spectral analysis. The compounds were screened for anticonvulsant and antimycobacterial activities. Antimycobacterial activity was screened using standard Strain H37RV and two Human Strains (Human strain-I and Human strain-II) isolated from patients suffering from pulmonary tuberculosis. The minimum inhibitory concentration (MIC) of C3, C5 , C6, C9 , against standard Strain H37RV was found to be 50-100 μg/mL, for Human strain-I and Human strain-II, the MIC was found to be 100-200 μg/mL. Anticonvulsant activity was tested in Wistar rats by maximal electro shock (MES) method. Compounds C1, C2 , C3, C4 , C5, C6 , C8, C13 and C14, showed significant anticonvulsant activity and compounds C9, C10 , C11 and C12 showed moderate activity.


Share this       
Google Scholar citation report
Citations : 9398

International Journal of Chemical Sciences received 9398 citations as per Google Scholar report

Indexed In

  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research
  • ICMJE

View More