Trikkattu Churanum was administered orally at doses of 100, 200, 400, 800 mg/kg/day to healthy mice’s divided into six groups consisting of three animals each. The assessment of immunomodulatory activity was carried out by testing the humoral (antibody titer) and cellular (foot pad swelling) immune responses to the antigenic challenge by sheep RBCs. On oral administration of test drug showed a significant increase in humoral antibody titer and delayed type hypersensitivity (DTH) response. With a dose of 400 mg/kg/day of test drug extract produced increase in humoral antibody (HA) titer as 180.2 ± 0.2a respectively, as compared to the untreated control group value is 8.5 ± 5.5 and potentiated the cellular immunity by facilitating the footpad thickness response to sheep RBCs in sensitized mice’s and the DTH response (Mean ± SD % increase in paw volume) was 0.43 ± 0.077a respectively, in comparison to the corresponding value of 0.31 ± 0.007 for the untreated control group. These differences in HA titer and DTH response were statistically significant (P<0.05). The study demonstrates that Trikkattu Churanum extract has promising immunostimulant properties.