Lagenaria siceraria (Cucurbitaceae), commonly known as Lauki (Hindi); Doodhi (Marathi); was used traditionally for cardiovascular diseases. The flavonoidal fraction of Lagenaria siceraria (FFLS) was studied for its effect on the triton induced hyperlipidemia in male albino rats. Oral administration of FFLS (10-40 mg/kg) significantly decreased the triglycerides (TG), total cholesterol (TC), low density lipoproteins (LDL) and very low density lipoproteins (VLDL). It also significantly increased the high density lipoproteins (HDL). The results obtained indicates the ability of flavonoidal fraction of Lagenaria siceraria to decrease the hyperlipidemia and thereby, decreasing the incidences of cardiovascular complications.