The present investigation deals with the photocatalytic degradation of Rose Bengal by using Ni (0.5, 1.0, 1.5 and 2.0 % by weight) doped titanium dioxide. The progress of the reaction was observed spectrophotometrically at 550 nm. The effect of various operating parameters like pH, concentration of dye, dose of semiconductor and light intensity has been studied to acheive optimal reaction conditions. A tentative mechanism has been proposed for the photocatalytic degradation of Rose Bengal, involving hydroxyl radical as an active oxidizing species. It was observed that the adsorption of Rose Bengal dye using Ni doped TiO2 follows pseudo-first order kinetics. This was observed that the degradation is more effective and fast for 0.5% Ni-TiO2.