Gas sweetening is a basic process in the gas refinery complexes. Undoubtedly, mixing of nano, sweetening and gas fuel can make revolution in the separation industries. Nano catalysts are adapted in this paper to vanish H S 2 as the toxic, corrosive and pyrophoric contaminant. The important feature which is considered is to improve the adsorption efficiency of hydrogen sulphide from hydrocarbon fuels such as methane gas by applying theAl2O3 as nano catalyst. Totally, the optimumconditions to eliminate the hydrogen sulphide from methane gas are evaluated in this paper, experimentally. In this paper, Al2O3 nano particles are synthesized and are contacted with flow of sour methane. The synthesized nano particles are characterized by SEM and TEM. The process performance of H S 2 removal from methane gas on Al2O3 nano particles is illustrated by the ratio of outlet concentration per feed concentration. The effects of operating conditions such as operating temperature and pressure, the amount of H S 2 concentration in feed stream, size of nano catalyst and the bed diameter are investigated in this paper. This work studies the adsorption of H S 2 from natural gas with an emphasis on the influence of the operating and geometric parameters on process efficiency.