Extractive Spectrophotometric Methods for Estimation of Citalopram Hydrobromide in Bulk and Pharmaceutical Formulation

Author(s): M. Sundarapandian, S. Venkataraman, M. Boopathi, V. Manoj Kumar and M. S. Prakash

Two simple economical, accurate and reproducible visible spectrophotometric methods (A and B) have been developed for the estimation of citalopram hydrobromide in bulk and tablet formulations.The developed methods are based on the formation of colored chloroform extractable ion-pair complexes of drug with bromocresol green (BCG) and bromophenol blue (BPB) in acidic medium.These chloroform extractable ion-pair complexes showed the absorption maxima at 415 nm. Beer’s law plot is linear over the concentration range of 5-20 μg/mL for both methods. The different experimental parameters affecting the development and stability were studied carefully and optimized. Results of analysis for both the methods were validated statistically and by recovery studies.

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