44 7460 854 031

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Development and Validation of Spectrophotometeric Methods for the Estimation of Cefditoren Pivoxil

Author(s): S. Appala Raju, Arvind B. Karadi and Shobha Manjunath

Three simple sensitive and economical spectrophotometric methods (A, B and C) for the quantitative estimation of cefditoren pivoxil in bulk drug and pharmaceutical dosage from have been developed. Method-A is based on UV absorption of drug in 0.1 N hydrocholoric acid exhibiting absorption maximum at 233 nm and it obyes Beer’s law in the concentration range of 1 to 5 μg/mL. Method-B (MBTH) is based on oxidation followed by coupling reaction of cefditoren pivoxil with 3- methyl-2-benzothiazolinone hydrazone (MBTH) in presence of ferric chloride to form purple coloured chromogen with absorption maxima max at 435 nm and obeyed Beer’s Law in the concentration range of 5-25 μg/mL. Method-C is based on the reaction of drug with folin-ciocalteau (FC) reagent in alkaline condition to from a stable blue coloured chromogen with absorption maximum at 760 nm and obeyed Beer’s law in the concentration range of 4 to 20 μg/mL. The results of the analysis for the three methods have been validated statically and by recovery studies. These method have been successfully extended to the pharmaceutical preparations (tablets) containing cefditoren.


Share this       
Google Scholar citation report
Citations : 9398

International Journal of Chemical Sciences received 9398 citations as per Google Scholar report

Indexed In

  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research
  • ICMJE

View More