A simple spectrophotometric method for the estimation of cisapride either in pure form or in tables has been developed. The developed spectrophotometric procedure was based on the reaction of cisapride with vanillin under acidic conditions to produce yellow coloured Schiff’s base. The absorbance of yellow coloured solution was measured after 15 min at 405 nm against reagent blank. Beer’s law was obeyed in the concentration of 80-200 μg/mL of drug. The method was successfully employed for the assay of cisapride in tablets.