Abstract

Antihelminthic and Antiinflammatory Activity of a Novel Series of New (1,3,4) Oxadiazino-[6,5-B]indole Derivatives

Author(s): K. S. Nataraj, J. Venkateshwara Rao, K. N. Jayaveera and K. Kesinath Reddy

In the present investigation, a novel series of 2-[(benzalamino-4-hydroxybenzyl) (1,3,4)- oxadiazino[6,5-b] Indole derivatives (V) has been synthesized. The synthesized compounds have been characterized by IR, 1H NMR and their mass number by mass spectroscopy. It was screened for antihelminthic activity using earthworms at 0.1%, 0.2%, 0.5% concentration of compounds compared to standard albendazole drug. Compounds V2, V9 and V16 showed good paralytic time, where as V3, V8, V10 and V11 showed moderate paralytic time of earthworms. Further, the synthesized compounds were screened for antiinflammatory activity by using Carrageenan–induced paw edema rat model. The results showed that the compounds significantly (p < 0.0001) reduced the inflammation, thereby showed a promising antiinflammatory activity. The synthesized compounds V2, V3, V4, V5, V7, V9, V11, V14, V15, V16, V18, V19, V20 and V21 showed potent activity (p < 0.0001), where as compound V1, V6, V8, V10, V12, V13 and V17 showed moderate activity (p < 0.05) in Carrageenan paw edema model on comparison with the standard drug diclofenac Sodium (10 mg/mL).