Drug resistance is a growing problem of 21st century. Therefore, to curb the drug resistant microbial infections, in the present study, we synthesized Schiff base, N-(3,5 dichlorosalicylidene)-4-(omethoxyphenyl)- 2-aminothiazole, by reacting 4-(o-methoxyphenyl)-2-aminothiazole and 3,5 dichlorosalicylaldehyde by microwave irradiation (a green chemistry approach) and conventional method. The as-synthesized Schiff bases were characterized by Uv-Visible, IR, 1H NMR, 13C NMR and GC-MS. The Schiff bases have inhibited the biofilm formations in Candida albicans MTCC 227. An amount of 100 ug of Schiff bases was sufficient to bring about more than 70% inhibition of biofilm in C. albicans. The biofilm inhibition by the action of Schiff bases was further evident from optical and scanning electron microscopic observations. Our study is the first report of the use of schiff bases as an inhibitor of biofilm formation in Candida albicans. The antibiofilm activity shown by Schiff bases is significant in biomedical field in controlling biofilm formed by C. albicanss and similar organisms.