Fluoride is most electronegative and most reactive halogen. Fluoride in the form of fluorine is 17th most common element on earth crust1. Concentration of fluoride below 1 ppm are believed beneficial in the prevention of dental carries or tooth decay, but above 1.5 ppm, it increases the severity of the deadly diseases fluorosis, which is incurable in India2. This paper alarm the latest scenario of fluorosis pollution in fifteen district of Madhya Pradesh, India. All water samples were taken for study from hydrograph stations in Madhya Pradesh. Fluoride in groundwater samples was found to range between nil to 14.20 ppm, while 33 % of water samples are within permissible limit of 1.5 ppm prescribed by BIS (1991). The highest value of fluoride (14.20 ppm) has been recorded at Seoni district in southern part of state. In western part, 13.86 ppm fluoride has been found in Jhabua district. In northern part, the high range of fluoride affects Gwalior and Shivpuri district. In central part of the province, 4.43 ppm concentration of fluoride was found at Vidisha district. This study was done in year 2006 and the maximum and minimum concentrations of fluoride are shown in different districts. The conclusion of this work is to give information about the deleterious changes of fluoride concentration in groundwater of the state.