In present study an efficient and mild synthesis of some diverse tetrazole containing benzothiazole moiety has been described using a multi-component reaction. Starting material 2-(piperazine-1-yl)-1,3-benzothiazole (3) was prepared by condensation between 2-(methylthio)benzothiazole (1) and piperazine (2) in microwave using alumina as a solid support. Microwave assisted synthesis using alumina as a solid support provides a green route for synthesis with high yield and short time as compared to conventional synthesis. 2-(Piperazine-1-yl)-1,3-benzothiazole on stirring with various aldehydes, TMSN3 and tert-butyl isocyanide in methanol led to tetrazoles containing benzothiazole moiety (4a-e). The synthesized compounds have been characterized on the basis of their elemental and spectral analysis.