A Detailed Study of Mouth Dissolving Drug Delivery System

Author(s): Ajoy Bera and Ashish Mukherjee

Patient compliance is one of the most important aspects in the pharmacy practice. In the pharmaceutical industry Oral delivery is currently regarded as the gold standard as it is safest, most convenient and most economical method of drug delivery having the highest patient compliance mouth dissolving drug delivery systems (MDDDS) take an important position in the market by overcoming previously encountered administration problems. Fast disintegrating tablets (FDTs) have received ever-increasing demand during the last decade, and Mouth Dissolving Tablets (MDT) are one of the fruitful results of these technological advancements. Upon introduction into the mouth, these FDT or MDT tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. A variety of drugs can be administered in the form of MD tablets as they give the advantage of the liquid medication in the solid preparation. Fast- or mouth dissolving tablets have been formulated for pediatric, geriatric, and bedridden patients and for active patients who are busy and traveling and may not have access to water. Technologies used for manufacturing of orally disintegrating tablets are either conventional technologies or patented technologies. In conventional freeze drying, tablet molding, sublimation, spray drying etc. and in patented tecnology such as Zydis, Orasolv, Durasolv, Wowtab and Flashdose technology are important. Important ingredients that are used in the formulation of ODTs should allow quick release of the drug, resulting in faster dissolution. This review describes the various formulation aspects, disintegrants employed and technologies developed for FDTs, patent formulation, evaluation tests, and marketed formulations

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