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Neisseria Meningitides

 Neisseria meningitidis (the meningococcus) causes critical bleakness and mortality in youngsters and youthful grown-ups worldwide through scourge or inconsistent meningitis as well as septicemia. In this survey, we depict the science, microbiology, and the study of disease transmission of this restrictive human pathogen. N. meningitidis is an exacting, exemplified, high-impact gram-negative diplococcus. Provinces are sure by the oxidase test and most strains use maltose. The phenotypic characterization of meningococci, in view of basic contrasts in capsular polysaccharide, lipooligosaccharide (LOS) and external film proteins, is presently supplemented by genome grouping composing (ST). The epidemiological profile of N. meningitidis is variable in various populaces and after some time and destructiveness of the meningococcus depends on a transformable/plastic genome and articulation of certain capsular polysaccharides (serogroups A, B, C, W-135, Y and X) and non-capsular antigens. N. meningitidis colonizes mucosal surfaces utilizing a multifactorial procedure including pili, jerking motility, LOS, darkness related, and other surface proteins. Certain clonal gatherings have an expanded ability to access the blood, sidestep natural invulnerable reactions, duplicate, and cause foundational malady. Albeit new immunizations hold incredible guarantee, meningococcal contamination keeps on being accounted for in both created and creating nations, where all inclusive antibody inclusion is missing and anti-toxin opposition progressively increasingly normal. 

  The meningococcus shares about 90% homology at the nucleotide level with either N. gonorrhoeae or N. lactamiea. Portable hereditary components including IS components and prophage successions make up to ~10% of the genome. Move of DNA happens between meningococci, gonococci, and commensal Neisseria spp. just as other microbes, (for example, Haemophilus). A few tedious arrangement and polymorphic districts are available, for the most part in huge heterogeneous clusters, proposing dynamic territories of hereditary recombination. Another trait of the meningococcal genome is the nearness of various hereditary switches (e.g., slipped-strand misparing, IS component development), adding to the statement of pathogen-related qualities (20). In synopsis, a focal trademark in the advancement of the meningococcus is the pliancy of the genome and the limit made by this versatility for decent variety of phenotype.

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Citations : 247

BioChemistry: An Indian Journal received 247 citations as per Google Scholar report

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