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Glucose-6-phosphate Dehydrogenase

 Glucose Phosphate enzyme participates in the pentose phosphate. Glucose-6-phosphate dehydrogenase is responsible for the first step in the pentose phosphate pathway, a series of chemical reactions that convert glucose pathway a metabolic pathway that supplies reducing energy to cells by maintaining the level of the co-enzyme in these cells that helps protect the red blood cells against oxidative damage from compounds like hydrogen peroxide nicotinamide adenine dinucleotide phosphate widely distributed in many species from bacteria to humans. Multiple sequence alignment of over 100 known G6PDs from different organisms reveal sequence identity ranging from 30% to 94%. Some scientists have proposed that some of the genetic variation in human G6PD resulted from generations of adaptation to malarial infection.  

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