While the clinico-pathological features of sickle cell disease take the center stage, be mindful of some of the enzymatic undertonesAuthor(s): K.Nsiah, V.P.Dzogbefia
Many texts on sickle cell disease (SCD) usually highlight on its pathophysiological features, and the clinical correlates, turning a blind eye, as it were, to the enzymatic actions behind these features. Even when authors touch on the enzymes, they are done in a piece-meal manner. This review looks at the various studies on sickle cell disease, in which the actions of enzymes underlying the SCD condition have been considered. The search engine used is HINARI, that allows free access (particularly to researchers like some of us in the developing countries) to some top biochemical and medical journals.