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Study of Serum Adiponectin and Oxidative Stress Levels in Patients with Type 2 Diabetes Mellitus

Author(s): Veerabhadra Goud GK, Veluri Ganesh, Siva Prasad Palem

Background: Serum Adiponectin is a specific protein synthesized from the adipocytes and kidney. Some of the recent studiesfound that increased level of serum adiponectin for early detection of nephropathy in Type 2 Diabetes Mellitus (T2DM). This protein has anti-diabetic, anti-oxidative properties and anti-inflammatory. Increased oxidative stress in patients with T2DM lead to some micro and macro vascular complications particularly kidney dysfunction. Estimation of serum adiponectin level may help to predict early detection of nephropathy in T2DM and the role of this protein complex. Therefore, we designed to evaluate the determinant serum adiponectin than urinary microalbuminuria for nephropathy in T2DM. Methods: This is a case control study, included 100 T2DM patients and further divided into two groups according to albumin-to-Creatinine ratio, T2DM patients with Normoalbuminuria (N=50), and Microalbuminuria (N=50), and 50 age and sex matched healthy controls also included. Urinary Albuminuria was analyzed by Albumin Creatinine Ratio (ACR), Serum Adiponectin Enzyme-Linked Immunosorbent Assay (ELISA) and serum MDA was analyzed by using TBARS Method. Results: The mean valuesof serum adiponectin (8.24 ± 2.36, 19.43 ± 3.08 and 23.94 ± 8.40) was significantly higher in T2DM patients with normoalbuminuria, Microalbuminuria, and Microalbuminuria, respectively. The serum MDA levels also elevated in three groups of T2DM patients compared to healthy controls. The significantly elevated levels of serum adiponectin observed in T2DM with Normoalbuminuria when compared to T2DM with Microalbuminuria and T2DM with Microalbuminuria. Conclusion: Elevated levels of serum adiponectin in T2DM with Normoalbuminuria and these levels are associated with renal insufficiency. Hence this study suggests that the estimation of adiponectin may useful for early detection and progression of nephropathy in T2DM patients.

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