Abstract

Serum malondialdehyde and thiol levels in patients with bipolar disorder

Author(s): Sonal Sukreet, Meghana Bhandarkar, Mahima B.Subramanyam, Madhur Agrawal, Abhishek Chaturvedi, Jeevan K.Shetty, Devaramane Virupaksha, Panambur V.Bhandary, Mungli Prakash

Bipolar disorder is a psychiatric diagnosis which shows unusual shifts in mood, energy, activity levels and the ability to carry out day to day works. Studies have suggested possible role of oxidative stress may play an important role in pathophysiology of neuropsychiatric disorders. In the current work, presence of oxidative damage in bipolar disorder is studied. Serum samples from 100 bipolar disorder patients and 52 healthy controls were collected to analyze lipid peroxidationmarkermalondialdehyde (MDA) and thiol levels using colorimetric methods. There was significant increase inMDA levels in bipolar patients (p<0.0001), although there was decrease in thiol levels in bipolar patients but it was not statistically significant. Serum thiol levels correlated negatively with MDA levels (r = -0.474, p<0.0001). Our study has shown the presence of oxidative membrane damage in bipolar disorder patients, supporting previous similar studies indicating role of oxidative free radicals in development of neuropsychiatric disorders.