Abstract

Nuclear phenotype modifications in human cell cultures after infection with encephalomyocarditis virus

Author(s): E.M.Karalova, N.G.Jaghatspanyan, L.H.Hakobyan, L.O.Abroyan, Z.R.Ter-Pogossyan, M.H.Gasparyan, A.S.Avetisyan, Z.A.Karalyan

RD human rhabdomyosarcoma cells and HEK 293-human embryonic kidney cells were infectedwith 0.1 TCD50/cell of the Columbia-SK strain of encephalomyocarditis virus (EMCV). EMCV was propagated in the RD and HEK 293 cell line and induced apoptosis. Resistant cells of the both cultures which surviving after lytic infection had differentiated phenotypic modifications, and can characterized by suppressed malignancy(suppressed proliferation rate, decreased DNA amount, increased euploidy, decreased of the average number of nucleoli).