Abstract

Molecular characterization of hemoglobin D â-thalassemia and clinico- hematological presentation of the patients

Author(s): Sanjay Pandey, Sweta Pandey, Rahasyamani Mishra, Renu Saxena

HbDâ conditions occur when the â-thalassemia co-inherits with hemoglobin D. Co-inheritance of alpha and beta thalassemia with HbD show the degree of clinical variability. Here we present the clinical variability of HbDâ+thalassemia and HbDâ0thalassemia patients due to presence of alpha deletions and beta mutations. Patients were diagnosed by HPLC while alpha and beta mutation studies done according to published literatures. Our data show clinical variation of HbDâ patients. They were behaved like thalassaemia intermedia and it was due to co-inheritance of alpha deletion and beta mutation.