Abstract

Hepatoprotective effect of Solanum trilobatum against mercury induced toxicity in rats

Author(s): P.Muthukumaran, S.Prabhu, K.Pattabiraman John Mohd

An attempt has been made to study the influence of Solanum trilobatum extract on mercury intoxicated rats. The animals were treated with sublethal dose of mercuric chloride (2mg/kg body wt.) for 30 days. During the mercury treatment, the level of Aspartate transaminase (AST), Alanine transaminase (ALT) and Alkaline phosphatase (ALP) in serum and lipid peroxidation (LPO) in liver tissue significantly increased and Reduced glutathione (GSH), Glutathione peroxidase (GPx), Catalase (CAT) and Superoxide dismutase (SOD) were simultaneously decreased in the respective tissue. This result indicates that the liver tissue was completely damaged. Aftermercury treatment, solanumtrilobatum extract (150mg/kg body wt.) was administrated inmercury intoxicated animals for another 15 days. Solanum trilobatum extract administration has improved the liver function inmercury intoxicated animal as indicated by declined in the increased level ofAST,ALT andALP in serum and LPO content in liver tissue. The decreased level of antioxidant system(GSH, GPx, CAT and SOD) has been promoted. This result suggested that Solanum trilobatum extract has play a vital role at the time of reducing the mercury toxicity in intoxicated animals.