Biocatalytic reduction of aromatic ketones with the aid of electrochemical regeneration of the coenzyme

Author(s): Tomoko Matsumura, Takamitsu Utsukihara, Kaoru Nakamura, Nakahide Katoh

Halogenated aromatic ketones were reduced electrochemically using dried cell of Geotrichum candidum as a catalyst with high enantioselectivity. Enzymes in the dried cell catalyzed both reactions to reduce substrates and to recycle the coenzyme using electric power, so any additional enzyme or co-substrate for coenzyme recycling was not necessary.

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