Abstract

Antihypertensive Activity of Methanolic Extract of Artemisia pallens Wall in Renal Hypertensive Diabetic Rats

Author(s): Nikhila Vengala

Hypertension and diabetes mellitus are chronic medical conditions that frequently coexist. The aim of the present study is to evaluate the effect of methanolic extract of Artemisia pallens Wall in hypertension induced by uninephrectomy in diabetic animals. Albino Wistar rats were used for the study. Diabetes was induced in rats by nicotinamide-STZ. After one week of diabetes induction rats were nephroctemized and animals were divided into seven groups: Sham control, Diabetic nepherectomy control, Glibenclamide treated group (5 mg/kg), Candesartan treated group (10 mg/kg), MEAP treated group (low dose i.e. 100 mg/kg), MEAP treated group (medium dose i.e. 200 mg/kg), MEAP treated group (high dose i.e. 400 mg/kg). The animals received Glibenclamide 5 mg/kg, Candesartan 10 mg/kg and received drug of MEAP 100, 200, 400 mg/kg, per oral respectively for 3 weeks for their respective groups. Treatment of MEAP (200 and 400 mg/kg) significantly decreased systolic blood pressure (p<0.001), diastolic blood pressure (p<0.001), heart rate (p<0.001) and significant increase in contractility index (p<0.001) indicating the effect on cardiac contractility. These findings were confirmed in histopathology. MEAP (200 and 400 mg/kg) showed significant (p<0.001) reduction in the glucose level showing antihyperglycemic effect