Abstract

Antidiabetic, antihyperlipidemic and histopathological analysis of Panax quinquefolium extract on alloxan induced diabetic rats

Author(s): M.A.Nagy

Objective: To investigate antidiabetic, hypolipidemic histopathological analysis of Panax quinquefolium aqueous (AGE) extract in alloxan induced diabetic rat by administering intraperitoneal dose (100mg/kg bodyweight / day). Methods: Optimal cutoff level of each of the four plasma glucose values of oral glucose tolerance test in alloxan diabetic rat was done. Other parameters as liver profile, renal profile and total lipid levels were determined in normal and alloxan induced diabetic rats after intraperitoneal administration of the extract for 30 days. Histopathological changes in diabetic rat organs (pancreas, liver and kidneywere also observed after extract treatment. Results: Daily intraperitoneal administration AGE (100 mg/kg body weight) and glimebride (10 microg/g body wt) showed beneficial effects on blood glucose level (P<0.001) as well as improving kidney, liver functions and hyperlipedemia due to diabetes. The extract treatment also showed enhanced serum insulin level and body weight of diabetic rats as compared to diabetic control group. Furthermore, the extract has a favorable effect on the histopathological changes of the pancreas, liver and kidney in alloxan induced diabetes. Conclusion: Panax quinquefoliumposses antidiabetic property as well as improve bodyweight, liver profile, renal profile and total lipid levels. AGE has also favorable effect to inhibit the histopathological changes of the pancreas and kidney in alloxan induced diabetes.