Zika virus (ZIKV) remained a comparatively incomprehensible animal virus to us so far. During a recent series of outbreaks with severe clinical complications, this virus came into the spotlight as a serious infective agent and raised worldwide public health concern. In this article, attempt was made to present the history and medical issues of ZIKV infection, recent outbreaks and also the emergence of ZIKV in different hemisphere. This article also focuses on recently reported complications of ZIKV infection together with Guillain-Barre syndrome and abnormality, potential interactions between ZIKV and break bone fever virus, and also the prospects for the event of antiviral agents and vaccines. Considering the recent outbreaks, it is important to increase the public awareness with more information related to the disease, symptoms, prevention and control.