Migraine, The most familiar word we come across at least once in a week. So, how did it all start? Everything started and is being continued since the evolution of the first human being[Homo Heildelbergensis)on the Planet. The book called “Ebers papyrus” written in 1500 BCE in ancient Egypt. It described the “visual aura preceding the headache[6-10] and a partial relief through vomiting[11-16]”. People who suffer Migraine have a severe recurrent throbbing headache that typically affects one side of the head and is often accompanied by nausea and disturbed vision. Here I have called migraine a portal, the reason will be revealed in the other parts of the article.