Abstract

Matrix metalloproteinase-1 genepolymorphism is associated with the prognosis of hepatocellular carcinoma in Egyptian population

Author(s): FatenZahran Mohamed, Ibrahim Mohey El-Deen, Islam Hamdy Mohamed, NerminRaafat Abdel Fattah

This study aimed to examine the relationship between the gene polymorphism ofMMP-1and the prognosis of hepatitisCvirus (HCV)-related hepatocellular carcinoma (HCC) in Egyptian population.Methods: The study enrolled 180 Egyptian individuals classified into 3 groupsGroup I: consists of 60 apparently healthy individuals served as control Group II: consists of 60 individuals diagnosed with HCV Group III: consists of 60 individuals diagnosed with HCC.Gene polymorphism of MMP-1 -16071G/2G using restriction fragment length polymorphism(RFLP) for amplified genomicDNA was analyzed.Results: In HCC prognosis, MMP-12G carriers hadhigher probability of developing HCC when compared to healthy individuals.Conclusion:MMP-1 2G allele may bea cooperative risk factor for poor prognosis in HCC patients, suggesting that further studies with larger sample size should be investigated to ensure that this gene polymorphism might be a potential marker for predicting the prognosis of HCC patients in Egyptian patients.