The systemic availability of curcumin is very low after oral administration; this limits their therapeutic potential. This study aims to increase the bioavailability of curcumin; the highest reproducible solubility modality will be applied on an experimental carcinogenesismodels in order to evaluate its chemo-preventive, chemotherapeutic effects and antitumor potential. We found that administrating of curcumin (200mg/kg I.P. bound to 5%BSA in PBS, pH7.4) results in a significant inhibitory effect on tumor in vivo.An anti-oxidant effect and anti-tumor effect of curcumin in vivo was observed. A significant reduction in anti-oxidants and tumor markers levels in tumor treated animals when compared with untreated ones. As well as Bcl2 expression was reduced. Conclusion: curcumin bound BSA has a strong inhibitory activity against tumors. The anti-tumor mechanism may be mediated by preventing oxidative damage and induction of apoptosis improved animalsÂ chances of survival and they become healthier.