The term benzodiazepine is the chemical name for the heterocyclic ring system, which is a fusion of benzene and diazepine ring systems. 1,4-benzodiazepine is related with a huge range of biological properties. These ring systems are incorporated into drugs used for AIDS, cancer, anti-viral treatment etc. 1,4-benzodiazepine derivatives are well established in the literature as important biologically active compounds. They have a long history of application in agrochemicals and pharmaceutical industry as herbicides and active pharmaceuticals. 1,4-benzodiazepine and their numerous derivatives have continued to capture the concentration of chemists since their existence in the biologically active materials have been known to produce additive effect on the bio-efficacy of the molecules.